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Re: Rapid drug screens in emergency departments

From: Robert Swotinsky MD
Date: 04 Feb 2005
Time: 08:43:47 -0800
Remote Name: 4.17.131.55

Comments

I have data for the "NIDA-5" drugs as follows:

 

Initial test assay confirmation rates amphetamines cocaine metabolites opiates PCP Marijuana metabolite
mean rate 51.9% 98.1% 30.2% 69.7% 91.0%
lowest rate 37.4% 91.1% 17.3% 51.6% 73.0%
highest rate 77.8% 99.9% 55.9% 91.0% 98.8%

What you see here is, of those specimens that screen positive by immunoassay, the percentage of specimens that also confirm positive by GC/MS.  The citation for these data is: Bush DM, et al.  Confirmation rates of initial drug assays in a group of HHS-certified laboratories.  January 01 through December 31, 2003. - 1. Federally regulated specimens.  Presented at: Joint meeting of the Society of Forensic Toxicologists and the International Association of Forensic Toxicologists.  Washington, DC.  2004.

Your question really asks about confirmation rates for benzodiazepine results.  I believe that data that responds to your question was presented at the same conference where the above-referenced data was presented.  However, the data on benzodiazepine (and other "non-NIDA") confirmation rates is complex and hard to interpret, since there are no standard cutoffs or standard target molecules for benzodiazepine analyses.  I don't have the benzodiazepine data to post.  If you really need it, you may be able to get a copy of that data from SAMHSA's drug testing office.