Drug and Alcohol Testing Q&A - 2008

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Re: Bupropion and amphetamine screen (+)

From: Dr. Steve
Password: orange
Date: 20 Mar 2008
Time: 07:54:54 -0800
Remote Name: 74.10.7.238

Comments

I have been doing MRO work for so long, that I can tell you that a great many substances can cause a great many of false positives in immunoassay screenings.  This is why all specimens that screen positive should be sent to the lab for GC/MS confirmation testing.   I have stopped maintaining a list of what drugs can cause false positives for "something" for exactly that reason.  Of note I have found an article that discusses such a case at this link: http://www3.interscience.wiley.com/cgi-bin/abstract/73001404/ABSTRACT?CRETRY=1&SRETRY=0.

There are a few other references I also saw that discuss this issue as well.

Screening tests are just that.  A rapid, usually inexpensive way to screen out the vast majority of negatives. However when looking for a drug they are very sensitive, but not that specific, and as such pick up a variety of false positives.