asolanomd wrote:I received a drug test report of a non-federal 10-panel that was confirmation-negative for everything except benzodiazipines. Next to benzodiazepines it had the comment, "alpha- hydroxyalprazolam - interference by GC/MS." When I spoke to the certifying scientist it was explained to me that there was a peak in the area expected for alprazolam but they couldn't quantify a level because of some interference. They couldn't say if the interference was possibly due to antibiotic or anti-inflammatory drug use. In interviewing the donor, he does admit to having a prescription for Xanax 1 mg and will have the pharmacy fax me documentation. He states that he is also on a BP med and Ultracet but has not been on any OTC Motrin or antibiotics. As previously mentioned, the other 9 test components in this panel are negative. If his explanation, including his documentation is valid, would this test be ruled negative or should it still be canceled and immediate recollection under direct observation?
gwoccmed wrote:While following the regulations is always defensible even on non-regulated, I have a slightly different approach for this non-regulated test. The lab verified negative the all but the alprazolam which was invalid (as a positive) because they couldn't get a stable quantification. Your donor can account for its presence but not the interference which now becomes moot. I'd save everyone a lot a trouble and simply call it negative. I also wouldn't lose any sleep over the idea of defending this as a negative in the extremely unlikely event of a challenge.
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