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Anticoagulants us should not disqualify truck drivers. If the driver has no deficits that interfere with operation of a commercial vehicle, then he should be cleared IF his INR is therapeutic, or he is using a new oral anticoagulant medication. His medical records should be requested and reviewed to make sure he is medically stable. The most frequent reason a patient is on an anticoagulant after a stroke ( instead of aspirin ) is a history of atrial fibrillation. Effective use of anticoagulants in atrial fibrillation reduce the risk of stroke, and he/she should be safe to drive.